EnoSTIM™ by Nexira is a proprietary synergistic formulation combining apple polyphenols, grape polyphenols, and saffron (Crocus sativus). Manufactured in France, it is clinically supported to enhance endothelial nitric oxide synthase (eNOS) activity, improving blood flow and reducing oxidative stress. Designed for use in men’s health and sexual health applications, EnoSTIM™ is a stable, water-soluble powder with recommended daily use levels of 300–600 mg. It has received international recognition for innovation in healthy aging.